AG-490
- Catalog NO.:A806630
- CAS No. : 133550-30-8
- Molecular Formula:C17H16N2O
- Molecular Weight: 264.32
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 133550-30-8 | Appearance | |
Catalog Number | A806630 | MDL Number | MFCD00236452 |
Molecular Formula | C17H16N2O | Molecular Weight | 264.32 |
Boiling Point | 615.2°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide;N-benzyl-2-cyano-3-cyclohexa-1,5-dien-1-yl-prop-2-enamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H317-H319 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. The hematopoietic cancer c-Kit+, Jak-2+ and non hematopoietic tumors c-Kit+, HER-2+, JAK-2+ can be inhibited by the chemosensitizing agent AG490 causing programmed cell death. |