Veliparib dihydrochloride

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For R&D use only.

Catalog NO.：A854345
CAS No. : 912445-05-7
Molecular Formula：C₁₃H₁₈Cl₂N₄O
Molecular Weight： 317.21

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Product Details

CAS Number	912445-05-7	Appearance	Coloreless to white crystalline solid
Catalog Number	A854345	MDL Number	MFCD12407402
Molecular Formula	C₁₃H₁₈Cl₂N₄O	Molecular Weight	317.21
Boiling Point		Melting Point
Flash Point		Density
Synonyms	Veliparib dihydrochloride
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H317	Class
Precautionary Statements	P280-P305+P351+P338	Packing Group

Description

Veliparib, also known as ABT-888, is a potent and selective Poly (ADP-Ribose) Polymerase (PARP) Inhibitor. Veliparib enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively).

912445-05-7 (Veliparib hydrochloride)

912444-00-9 (Veliparib free base)

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P102	Keep out of reach of children.
P103	Read label before use

P201	Obtain special instructions before use.
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P220	Keep/Store away from clothing/…/combustible materials.
P221	Take any precaution to avoid mixing with combustibles/…
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted with …
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P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool.
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P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
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P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
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P235 + P410	Keep cool. Protect from sunlight.

P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
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P378	Use … for extinction.
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire: Use … for extinction.
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371	In case of major fire and large quantities:
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P401	Store …
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P404	Store in a closed container.
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P406	Store in corrosive resistant/… container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
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P501	Dispose of contents/container to..…
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