PPQ-102
- Catalog NO.:A857441
- CAS No. : 931706-15-9
- Molecular Formula:C26H22N4O3
- Molecular Weight: 438.48
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 931706-15-9 | Appearance | |
Catalog Number | A857441 | MDL Number | MFCD14824240 |
Molecular Formula | C26H22N4O3 | Molecular Weight | 438.48 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 7,9-dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(7H,9H)-dione | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H317 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
PPQ-102 is a potent and selective CFTR inhibitor. PPQ-102, completely inhibited CFTR chloride current with IC(50) approximately 90 nM. Patch-clamp analysis confirmed voltage-independent CFTR inhibition by PPQ-102 and showed stabilization of the channel closed state. PPQ-102 prevented cyst expansion and reduced the size of preformed cysts in a neonatal kidney organ culture model of polycystic kidney disease. PPQ-102 is the most potent CFTR inhibitor identified to date. |