AZ 628
- Catalog NO.:A862378
- CAS No. : 878739-06-1
- Molecular Formula:C27H25N5O2
- Molecular Weight: 451.52
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
SDS
Product Details
CAS Number | 878739-06-1 | Appearance | Solid |
Catalog Number | A862378 | MDL Number | MFCD17392577 |
Molecular Formula | C27H25N5O2 | Molecular Weight | 451.52 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 3-(1-Cyano-1-Methylethyl)-N-[3-[(3,4-dihydro-3-Methyl-4-oxo-6-quinazolinyl)aMino]-4-Methylphenyl]benzaMide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Danger | UN Number | 2811 |
Hazard Statements | H301-H315-H319-H335 | Class | 6.1 |
Precautionary Statements | P261-P301+P310-P305+P351+P338 | Packing Group | Ⅲ |
Description
AZ-628 is a selective, orally available Raf inhibitor with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies ( (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). AZ-628 inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation. |