Lenvatinib
- Catalog NO.:A825653
- CAS No. : 417716-92-8
- Molecular Formula:C21H19ClN4O4
- Molecular Weight: 426.85
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 417716-92-8 | Appearance | White powder |
Catalog Number | A825653 | MDL Number | MFCD16038644 |
Molecular Formula | C21H19ClN4O4 | Molecular Weight | 426.85 |
Boiling Point | 627.2°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide; E7080 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Lenvatinib is a potent inhibitor of multiple receptor tyrosine kinases, with IC₅₀ values of 22 nM, 4 nM, 5.2 nM, 39 nM and 35 nM on VEGFR-1, VEGFR-2, VEGFR-3, PDGFRβ and RET, respectively. It inhibits SCF- and VEGF-induced angiogenesis of human umbilical vein endothelial cells that express the SCF receptor KIT, with IC₅₀ values of 5.2 nM and 5.1 nM, respectively. Lenvatinib inhibits tumor growth in the human small cell lung cancer H146 xenograft model. |