PA-824
- Catalog NO.:A855886
- CAS No. : 187235-37-6
- Molecular Formula:C14H12F3N3O5
- Molecular Weight: 359.26
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Product Details
CAS Number | 187235-37-6 | Appearance | Off-white solid |
Catalog Number | A855886 | MDL Number | MFCD06809939 |
Molecular Formula | C14H12F3N3O5 | Molecular Weight | 359.26 |
Boiling Point | Melting Point | 149-150℃ | |
Flash Point | Density | ||
Synonyms | Pretomanid;(6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Pretomanid, aslo known as PA-824, a bioreductive drug. PA-824 has potent in vitro activity against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates (MIC<1 microg/ml). PA-824 showed significant activity at 2, 10, and 50 microg/ml, similar to that of metronidazole, in a dose-dependent manner. PA-824's good activity in in vivo models, as well as its activity against multidrug-resistant M. tuberculosis and against M. tuberculosis isolates in a potentially latent state, makes PA-824 an attractive drug candidate for the therapy of tuberculosis. |