For R&D use only.

Bafilomycin A1

  • Catalog NO.:A861384
  • CAS No. : 88899-55-2
  • Molecular Formula:C35H58O9
  • Molecular Weight: 622.84
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Product Details

CAS Number 88899-55-2 Appearance White powder
Catalog Number A861384 MDL Number MFCD06795130
Molecular Formula C35H58O9 Molecular Weight 622.84
Boiling Point 770.1°C at 760 mmHg Melting Point
Flash Point Density
Synonyms (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H315-H319-H335 Class
Precautionary Statements P261-P305+P351+P338 Packing Group

Description

Bafilomycin A1, also known as NSC 381866, is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range. Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice. Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways.

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Bafilomycin A1
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one