AR-13324 dihydrochloride

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For R&D use only.

Catalog NO.：A904052
CAS No. : 1253952-02-1
Molecular Formula：C₂₈H₂₉Cl₂N₃O₃
Molecular Weight： 526.46

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	1253952-02-1	Appearance	Off-white powder
Catalog Number	A904052	MDL Number	MFCD29472289
Molecular Formula	C₂₈H₂₉Cl₂N₃O₃	Molecular Weight	526.46
Boiling Point		Melting Point
Flash Point		Density
Synonyms	(S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate dihydrochloride
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.

1422144-42-0 (mesylate)

1254032-66-0 (free base)

1253952-02-1 (HCl)

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