PCI-34051
- Catalog NO.:A859205
- CAS No. : 950762-95-5
- Molecular Formula:C17H16N2O3
- Molecular Weight: 296.32
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
SDS
Product Details
CAS Number | 950762-95-5 | Appearance | White to Off-white Solid |
Catalog Number | A859205 | MDL Number | MFCD11114393 |
Molecular Formula | C17H16N2O3 | Molecular Weight | 296.32 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor with >200-fold selectivity over the other HDAC isoforms. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. Unlike broad-spectrum HDAC inhibitors, PCI-34051 does not cause detectable histone or tubulin acetylation. PCI-34051 could offer benefits including a greater therapeutic index for treating T-cell malignancies. |