Selisistat
- Catalog NO.:A21392
- CAS No. : 49843-98-3
- Molecular Formula:C13H13ClN2O
- Molecular Weight: 248.71
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 49843-98-3 | Appearance | Off-white to light yellow powder |
Catalog Number | A21392 | MDL Number | MFCD03009471 |
Molecular Formula | C13H13ClN2O | Molecular Weight | 248.71 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | EX-527;6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H317-H319 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
Selisistat, also known as EX-527, is a SirT1 inhibitor for treatment of Huntington's disease. EX-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Galectin-9 in Combination With EX-527 Prolongs the Survival of Cardiac Allografts in Mice After Cardiac Transplantation. Ex-527 is widely used as a major inhibitor of Sirtuin enzymes, which are a family of highly conserved protein deacetylases and have been linked with caloric restriction and aging by modulating energy metabolism, genomic stability, and stress resistance. |