Alectinib
- Catalog NO.:A856347
- CAS No. : 1256580-46-7
- Molecular Formula:C30H34N4O2
- Molecular Weight: 482.62
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Product Details
CAS Number | 1256580-46-7 | Appearance | White to off-white solid |
Catalog Number | A856347 | MDL Number | MFCD19440988 |
Molecular Formula | C30H34N4O2 | Molecular Weight | 482.62 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 9-ethyl-6,6-diMethyl-8-(4-Morpholinopiperidin -1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Alectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. Alectinib inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth. Alectinib (as HCl salt) was approved in Dec. 2015. |