AG-1024
- Catalog NO.:A854352
- CAS No. : 65678-07-1
- Molecular Formula:C14H13BrN2O
- Molecular Weight: 305.17
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 65678-07-1 | Appearance | |
Catalog Number | A854352 | MDL Number | MFCD02179365 |
Molecular Formula | C14H13BrN2O | Molecular Weight | 305.17 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile;Tyrphostin | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation. |