VRT752271 HCl hydrate
- Catalog NO.：A904736
- CAS No. : 1975172-95-2
- Molecular Formula：C21H25Cl3N4O3
- Molecular Weight： 487.81
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Product Details
| CAS Number | 1975172-95-2 | Appearance | |
| Catalog Number | A904736 | MDL Number | |
| Molecular Formula | C21H25Cl3N4O3 | Molecular Weight | 487.81 |
| Boiling Point | Melting Point | ||
| Flash Point | Density | ||
| Synonyms | (S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide hydrochloride hydrate | ||
| Storage Condition | Store in a tightly closed container,in a cool and dry place | ||
Safety
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| Signal Word | Warning | UN Number | |
| Hazard Statements | Class | ||
| Precautionary Statements | Packing Group | ||
Description
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Ulixertinib, also known as BVD-523 and VRT752271, is an inhibitors of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. |
