P005091
- Catalog NO.:A862277
- CAS No. : 882257-11-6
- Molecular Formula:C12H7Cl2NO3S2
- Molecular Weight: 348.22
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 882257-11-6 | Appearance | |
Catalog Number | A862277 | MDL Number | MFCD00123202 |
Molecular Formula | C12H7Cl2NO3S2 | Molecular Weight | 348.22 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 1-(5-((2,3-dichlorophenyl)thio)-4-nitrothiophen-2-yl)ethanone | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Danger | UN Number | 2811 |
Hazard Statements | H301-H413 | Class | 6.1 |
Precautionary Statements | P301+P310 | Packing Group | Ⅲ |
Description
P005091 is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μ M). P005091 induces elevated p53 and apoptosis in cancer cell lines and displays antiangiogenic activity in vivo . The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention. |