- Catalog NO.：A854255
- CAS No. : 1143532-39-1
- Molecular Formula：C21H25ClN6O2
- Molecular Weight： 428.92
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|CAS Number||1143532-39-1||Appearance||White powder|
|Catalog Number||A854255||MDL Number||MFCD22628785|
|Molecular Formula||C21H25ClN6O2||Molecular Weight||428.92|
|Boiling Point||Melting Point|
|Storage Condition||Store in a tightly closed container,in a cool and dry place|
|Signal Word||Warning||UN Number|
|Precautionary Statements||P261-P305+P351+P338||Packing Group|
AZD5363, also known as Capivasertib, is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AKT inhibitor AZD5363 binds to and inhibits all AKT isoforms. Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism. A wide range of solid and hematological malignancies show dysregulated PI3K/AKT/mTOR signaling due to mutations in multiple signaling components.