AGI-5198
- Catalog NO.:A854356
- CAS No. : 1355326-35-0
- Molecular Formula:C27H31FN4O2
- Molecular Weight: 462.56
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
SDS
Product Details
CAS Number | 1355326-35-0 | Appearance | Crystalline solid |
Catalog Number | A854356 | MDL Number | MFCD24848688 |
Molecular Formula | C27H31FN4O2 | Molecular Weight | 462.56 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity. AGI-5198 shows good potency in the U87 R132H cell based assay and ~90% tumor 2-HG inhibition in the corresponding mouse xenograft model following BID dosing. AGI-5198 inhibits IDH1 R132H mutant and R132C mutant in vitro with IC50 ~0.07 μM and ~0.16 μM, respectively. |