Rucaparib phosphate

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For R&D use only.

Catalog NO.：A24480
CAS No. : 459868-92-9
Molecular Formula：C₁₉H₂₁FN₃O₅P
Molecular Weight： 421.36

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	459868-92-9	Appearance	Yellow powder
Catalog Number	A24480	MDL Number	MFCD17010269
Molecular Formula	C₁₉H₂₁FN₃O₅P	Molecular Weight	421.36
Boiling Point		Melting Point
Flash Point		Density
Synonyms	PF-01367338;Rucaparib phosphate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H332-H335	Class
Precautionary Statements	P280-P305+P351+P338-P310	Packing Group

Description

Rucaparib, also known as AG-14699 or PF-01367338, is a tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy.

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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire: Use … for extinction.
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