Crizotinib acetate

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For R&D use only.

Catalog NO.：A904058
CAS No. : 877399-53-6
Molecular Formula：C₂₃H₂₆Cl₂FN₅O₃
Molecular Weight： 510.39

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Product Details

CAS Number	877399-53-6	Appearance
Catalog Number	A904058	MDL Number
Molecular Formula	C₂₃H₂₆Cl₂FN₅O₃	Molecular Weight	510.39
Boiling Point		Melting Point
Flash Point		Density
Synonyms	(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine acetate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements		Class
Precautionary Statements		Packing Group

Description

Crizotinib, also known as PF-02341066, is an orally bioavailable agent belonging to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. Crizotinib was approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and childre. Crizotinib inhibits the membrane receptor MET and activation of the MET signaling pathway, which may block tumor cell growth, migration and invasion, and tumor angiogenesis in susceptible tumor cell populations. Crizotinib was approved in 2011.

877399-53-6 (acetate)

877399-52-5 (free base)

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