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ITE
- Catalog NO.:A22724
- CAS No. : 448906-42-1
- Molecular Formula:C14H10N2O3S
- Molecular Weight: 286.31
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 448906-42-1 | Appearance | Light yellow powder |
Catalog Number | A22724 | MDL Number | MFCD06411597 |
Molecular Formula | C14H10N2O3S | Molecular Weight | 286.31 |
Boiling Point | 520.4°C at 760 mmHg | Melting Point | |
Flash Point | 268.5oC | Density | 1.427g/cm3 |
Synonyms | 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylicacidMethylester | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). It enhances differentiation of cancer stem-like cells detected by the decrease of sphere formation and proliferation from glioblastoma cells U87. Mechanically, ITE bound AhR inhibits transcription of OCT4, an inducer of pluripotent stem cells, through direct binding to OCT4 promoter. As a consequence, ITE treatment significantly represses the tumor formation in xenograft model using injection of U87 cells. |