KU57788
- Catalog NO.:A25180
- CAS No. : 503468-95-9
- Molecular Formula:C25H19NO3S
- Molecular Weight: 413.49
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
SDS
Product Details
CAS Number | 503468-95-9 | Appearance | Off-white solid |
Catalog Number | A25180 | MDL Number | MFCD11983069 |
Molecular Formula | C25H19NO3S | Molecular Weight | 413.49 |
Boiling Point | 646.9°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | NU7441;8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one;NU7441;NU7441 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
NU7441, also known as KU-57788, is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB. |