LDK378 dihydrochloride

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For R&D use only.

Catalog NO.：A886318
CAS No. : 1380575-43-8
Molecular Formula：C₂₈H₃₈Cl₃N₅O₃S
Molecular Weight： 631.06

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Product Details

CAS Number	1380575-43-8	Appearance
Catalog Number	A886318	MDL Number	MFCD26142928
Molecular Formula	C₂₈H₃₈Cl₃N₅O₃S	Molecular Weight	631.06
Boiling Point		Melting Point
Flash Point		Density
Synonyms	5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine hydrochloride (1:2)
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P301+P312-P302+P352-P304+P340-P305+P351+P338	Packing Group

Description

Ceritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib. LDK378 blocks the ALK protein and stops it sending growth signals to cancer cells, which may stop them growing. Ceritinib was approved in April 2014.

1032900-25-6 (free base)

1380575-43-8 (2HCl)

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