Palomid 529
- Catalog NO.:A25456
- CAS No. : 914913-88-5
- Molecular Formula:C24H22O6
- Molecular Weight: 406.43
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 914913-88-5 | Appearance | White to off-white solid |
Catalog Number | A25456 | MDL Number | MFCD18633224 |
Molecular Formula | C24H22O6 | Molecular Weight | 406.43 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | P529;8-(1-hydroxyethyl)-2-methoxy-3-((4-methoxybenzyl)oxy)-6H-benzo[c]chromen-6-one | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Danger | UN Number | 2811 |
Hazard Statements | H301 | Class | 6.1 |
Precautionary Statements | P301+P310 | Packing Group | III |
Description
Palomid 529, also known as P529, is a novel PI3K/Akt/mTOR inhibitor. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. It was demonstrated that P529 inhibited tumor growth, angiogenesis, and vascular permeability. It retained the beneficial aspects of tumor vascular normalization that rapamycin boasts. However, P529 showed the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells. |