Dabrafenib Mesylate

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For R&D use only.

Catalog NO.：A903491
CAS No. : 1195768-06-9
Molecular Formula：C₂₄H₂₄F₃N₅O₅S₃
Molecular Weight： 615.66

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Product Details

CAS Number	1195768-06-9	Appearance
Catalog Number	A903491	MDL Number	MFCD20922872
Molecular Formula	C₂₄H₂₄F₃N₅O₅S₃	Molecular Weight	615.66
Boiling Point		Melting Point
Flash Point		Density
Synonyms	Dabrafenib mesylate；N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide, methanesulfonic acid; Dabrafenib Mesylate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Dabrafenib mesylate, also known as GSK 2118436B, is a potent and orally active B-raf (BRAF) inhibitor with in vitro IC50 values of 0.65, 0.5, and 1.84 nM for BRAF V600E, BRAF V600K, and BRAF V600D enzymes, respectively. Dabrafenib also inhibits wild-type BRAF and CRAF kinases with IC50 values of 3.2 and 5.0 nM, respectively, and other kinases such as SIK1, NEK11, and LIMK1 at higher concentrations. Some mutations in the BRAF gene, including those that result in BRAF V600E, can result in constitutively activated BRAF kinases that may stimulate tumor cell growth. Dabrafenib inhibits BRAF V600 mutation-positive melanoma cell growth in vitro and in vivo.

1195765-45-7 (free base)

1195768-06-9 (mesylate)

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