Nepicastat hydrochloride

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For R&D use only.

Catalog NO.：A882044
CAS No. : 170151-24-3
Molecular Formula：C₁₄H₁₆ClF₂N₃S
Molecular Weight： 331.81

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Quality Control&SDS

Product Details

CAS Number	170151-24-3	Appearance
Catalog Number	A882044	MDL Number	MFCD00954638
Molecular Formula	C₁₄H₁₆ClF₂N₃S	Molecular Weight	331.81
Boiling Point		Melting Point
Flash Point		Density
Synonyms	(S)-5-(aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thione hydrochloride
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Nepicastat, also known as SYN117 and RS-25560-197, is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. It has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated. As of 2012, clinical trials to assess nepicastat as a treatment for post-traumatic stress disorder (PTSD) and cocaine dependence have been completed. In Phase 2 study treatment with nepicastat was not effective in relieving PTSD-associated symptoms when compared to placebo.

170151-24-3 (HCl)

173997-05-2 (free base)

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