ON 01910 sodiuM salt

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For R&D use only.

Catalog NO.：A857758
CAS No. : 1225497-78-8
Molecular Formula：C₂₁H₂₄NNaO₈S
Molecular Weight： 473.47

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Quality Control&SDS

SDS COA HPLC/GC NMR

Product Details

CAS Number	1225497-78-8	Appearance
Catalog Number	A857758	MDL Number	MFCD11655911
Molecular Formula	C₂₁H₂₄NNaO₈S	Molecular Weight	473.47
Boiling Point		Melting Point
Flash Point		Density
Synonyms	N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-glycine,sodium salt (1:1);Rigosertib Sodium(Random Configuration)
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Rigosertib (ON-01910 sodium salt) is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo-like kinase 1 inhibitor ON 01910.Na inhibits polo-like kinase1 (Plk1), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.

1225497-78-8 (sodium)

592542-59-1 (free acid)

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