Regorafenib(BAY 73-4506)

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For R&D use only.

Catalog NO.：A25020
CAS No. : 755037-03-7
Molecular Formula：C₂₁H₁₅ClF₄N₄O₃
Molecular Weight： 482.82

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Product Details

CAS Number	755037-03-7	Appearance
Catalog Number	A25020	MDL Number	MFCD16038047
Molecular Formula	C₂₁H₁₅ClF₄N₄O₃	Molecular Weight	482.82
Boiling Point	513.4°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea;Regorafenib
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Regorafenib, also known as BAY 73-4506 ; is a n orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. Regorafenib demonstrated to increase the overall survival of patients with metastatic colorectal cancer and has been approved by the US FDA on September 27, 2012.

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