Linifanib (ABT-869)

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For R&D use only.

Catalog NO.：A19393
CAS No. : 796967-16-3
Molecular Formula：C₂₁H₁₈FN₅O
Molecular Weight： 375.40

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Quality Control&SDS

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Product Details

CAS Number	796967-16-3	Appearance	White powder
Catalog Number	A19393	MDL Number	MFCD11840918
Molecular Formula	C₂₁H₁₈FN₅O	Molecular Weight	375.40
Boiling Point		Melting Point
Flash Point		Density
Synonyms	1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea;Linifanib
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Linifanib, also known as ABT-869, is an orally bioavailable, small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Linifanib inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families; it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. This agent does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as fms-related tyrosine kinase receptor-3 (FLT3).

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