CP640186 HCl
- Catalog NO.:A904056
- CAS No. : 591778-70-0
- Molecular Formula:C30H36ClN3O3
- Molecular Weight: 522.08
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Product Details
CAS Number | 591778-70-0 | Appearance | White to off-white solid |
Catalog Number | A904056 | MDL Number | |
Molecular Formula | C30H36ClN3O3 | Molecular Weight | 522.08 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (R)-anthracen-9-yl(3-(morpholine-4-carbonyl)-[1,4'-bipiperidin]-1'-yl)methanone hydrochloride;CP-640186 hydrochloride | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
CP-640186 is a potent inhibitor of mammalian ACCs and can reduce body weight and improve insulin sensitivity in test animals. CP-640186 has recently been shown to be a potent inhibitor of isoforms of mammalian ACCs with IC50 values of about 55 nM. This is currently the only reported potent inhibitor of mammalian ACCs. In cell cultures as well as in animal models, CP-640186 can reduce tissue malonyl-CoA levels, inhibit fatty acid biosynthesis, and stimulate fatty acid oxidation. Most importantly, CP-640186 can reduce body fat mass and body weight, and improve insulin sensitivity, validating ACCs as targets for antiobesity and antidiabetes drugs. |