GSK429286A
- Catalog NO.:A19412
- CAS No. : 864082-47-3
- Molecular Formula:C21H16F4N4O2
- Molecular Weight: 432.37
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
SDS
Product Details
CAS Number | 864082-47-3 | Appearance | White powder |
Catalog Number | A19412 | MDL Number | MFCD16618404 |
Molecular Formula | C21H16F4N4O2 | Molecular Weight | 432.37 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Danger | UN Number | 2811 |
Hazard Statements | H301 | Class | 6.1 |
Precautionary Statements | P301+P310 | Packing Group | Ⅲ |
Description
GSK429286A is a selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active. |