BMS 794833
- Catalog NO.:A857638
- CAS No. : 1174046-72-0
- Molecular Formula:C23H15ClF2N4O3
- Molecular Weight: 468.84
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Product Details
CAS Number | 1174046-72-0 | Appearance | |
Catalog Number | A857638 | MDL Number | MFCD18206786 |
Molecular Formula | C23H15ClF2N4O3 | Molecular Weight | 468.84 |
Boiling Point | 637.2±55.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | N-[4-((2-Amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide;BMS-794833 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM. BMS-794833 also inhibits Ron (Met family), Axl (phylogenetically related Axl/Tyro3/Mer subfamily) and Flt-3 with IC50 values less than 3 nM. The compound was selective versus a panel of greater than 200 additional receptor tyrosine kinase (RTKs), non-RTKs and serine/threonine kinases based on biochemical or Ambit binding assays. Moreover, it inhibited the cell growth in GTL-16 gastric carcinomas with an IC50 of 39 nM . In vivo, BMS-794833 exhibited dose-dependent anti-tumor activity against multiple tumor types without overt toxicities at efficacious dose levels. |