SAL003
- Catalog NO.:A893567
- CAS No. : 1164470-53-4
- Molecular Formula:C18H15Cl4N3Os
- Molecular Weight: 463.21
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 1164470-53-4 | Appearance | |
Catalog Number | A893567 | MDL Number | |
Molecular Formula | C18H15Cl4N3Os | Molecular Weight | 463.21 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Danger | UN Number | 3077 |
Hazard Statements | H410 | Class | 9 |
Precautionary Statements | P273 | Packing Group | Ⅲ |
Description
SAL-003 is a cell-permeable inhibitor of eIF2α dephosphorylation. SAL003 is an Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Sal003‑mediated upregulation of eIF2α phosphorylation suppressed cisplatin‑induced p53 activation. Furthermore, reduction of eIF2α phosphorylation by PERK knockdown enhanced cisplatin-induced p53 activation and apoptosis. |