Mocetinostat
- Catalog NO.:A846294
- CAS No. : 726169-73-9
- Molecular Formula:C23H20N6O
- Molecular Weight: 396.45
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Product Details
CAS Number | 726169-73-9 | Appearance | White to off-white solid |
Catalog Number | A846294 | MDL Number | MFCD10565970 |
Molecular Formula | C23H20N6O | Molecular Weight | 396.45 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Mocetinostat, also known as MGCD-0103, is a rationally designed, orally available, Class 1-selective, small molecule, 2-aminobenzamide HDAC inhibitor with potential antineoplastic activity. Mocetinostat binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others. |