Tacrolimus monohydrate

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For R&D use only.

Catalog NO.：A930321
CAS No. : 109581-93-3
Molecular Formula：C₄₄H₇₁NO₁₃
Molecular Weight： 822.05

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Quality Control&SDS

SDS COA LC-MS/GC-MS NMR

Product Details

CAS Number	109581-93-3	Appearance	White powder
Catalog Number	A930321	MDL Number	MFCD11045918
Molecular Formula	C₄₄H₇₁NO₁₃	Molecular Weight	822.05
Boiling Point	871.7°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-, hydrate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	2811
Hazard Statements	H301	Class	6.1
Precautionary Statements	P301+P310	Packing Group	Ⅲ

Description

Navitoclax, also known as ABT-263, is an orally bioavailable, synthetic small-molecule antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. ABT-263 selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.

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