tert-butyl rel-(1R,4R,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

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For R&D use only.

Catalog NO.：A937299
CAS No. : 198835-07-3
Molecular Formula：C₁₁H₁₉NO₃
Molecular Weight： 213.27

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Product Details

CAS Number	198835-07-3	Appearance
Catalog Number	A937299	MDL Number
Molecular Formula	C₁₁H₁₉NO₃	Molecular Weight	213.27
Boiling Point		Melting Point
Flash Point		Density
Synonyms	tert-butyl rel-(1R,4R,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
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Hazard Statements		Class
Precautionary Statements		Packing Group

Description

Navitoclax, also known as ABT-263, is an orally bioavailable, synthetic small-molecule antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. ABT-263 selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.

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