1-(4-Cyanobutyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide

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For R&D use only.

Catalog NO.：A937668
CAS No. : 1631074-54-8
Molecular Formula：C₂₂H₂₄N₄O
Molecular Weight： 360.46

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Product Details

CAS Number	1631074-54-8	Appearance
Catalog Number	A937668	MDL Number
Molecular Formula	C₂₂H₂₄N₄O	Molecular Weight	360.46
Boiling Point		Melting Point
Flash Point		Density
Synonyms	1-(4-Cyanobutyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

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Description

MGL-3196 is a potent and highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia. The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). MGL-3196 shows outstanding safety in a rat heart model and is efficacious in a preclinical model at doses that showed no impact on the central thyroid axis.

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