Hexane-1,6-dioic acid bis(pentafluorophenyl) ester
- Catalog NO.:A943421
- CAS No. : 83701-40-0
- Molecular Formula:C18H8F10O4
- Molecular Weight: 478.24
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Product Details
CAS Number | 83701-40-0 | Appearance | White powder |
Catalog Number | A943421 | MDL Number | |
Molecular Formula | C18H8F10O4 | Molecular Weight | 478.24 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | Hexane-1,6-dioic acid bis(pentafluorophenyl) ester | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302;H315;H319;H335 | Class | |
Precautionary Statements | P261;P305+P351+P338 | Packing Group |
Description
KC7F2 is a potent HIF-1 pathway inhibitor with potential anticancer activity. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 µM. KC7F2 markedly inhibited HIF-mediated transcription in cells derived from different tumor types, including glioma, breast, and prostate cancers, and exhibited enhanced cytotoxicity under hypoxia. KC7F2 prevented the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), endothelin 1, and enolase 1. KC7F2 worked through the down-regulation of HIF-1alpha protein synthesis, an effect accompanied by the suppression of the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1alpha protein synthesis. |