For R&D use only.

1,1-Dibromoethane (stabilized with Copper chip)

  • Catalog NO.:A943497
  • CAS No. : 557-91-5
  • Molecular Formula:C2H4Br2
  • Molecular Weight: 187.86
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Product Details

CAS Number 557-91-5 Appearance Colorless liquid
Catalog Number A943497 MDL Number MFCD00041719
Molecular Formula C2H4Br2 Molecular Weight 187.86
Boiling Point 107 °C Melting Point -63°C
Flash Point Density 2.06
Synonyms 1,1-Dibromoethane (stabilized with Copper chip)
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Danger UN Number 2810
Hazard Statements H301;H311;H315;H319;H331 Class 6.1
Precautionary Statements P264;P270;P280;P261;P271;P301+P316;P321;P330;P302+P352;P316;P361+P364;P330+P317;P362+P364;P332+P317;P362+P364;P305+P351+P338;P304+P340;P405;P403+P233;P501 Packing Group III

Description

KC7F2 is a potent HIF-1 pathway inhibitor with potential anticancer activity. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 µM. KC7F2 markedly inhibited HIF-mediated transcription in cells derived from different tumor types, including glioma, breast, and prostate cancers, and exhibited enhanced cytotoxicity under hypoxia. KC7F2 prevented the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), endothelin 1, and enolase 1. KC7F2 worked through the down-regulation of HIF-1alpha protein synthesis, an effect accompanied by the suppression of the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1alpha protein synthesis.

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1,1-Dibromoethane (stabilized with Copper chip)
1,1-Dibromoethane (stabilized with Copper chip)