((1-(tert-Butoxy)vinyl)oxy)(tert-butyl)dimethylsilane
- Catalog NO.:A946041
- CAS No. : 74786-02-0
- Molecular Formula:C12H26O2Si
- Molecular Weight: 230.42
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 74786-02-0 | Appearance | Colorless liquid |
Catalog Number | A946041 | MDL Number | MFCD12923224 |
Molecular Formula | C12H26O2Si | Molecular Weight | 230.42 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | ((1-(tert-Butoxy)vinyl)oxy)(tert-butyl)dimethylsilane | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302;H315;H319;H335 | Class | |
Precautionary Statements | P261;P305+P351+P338 | Packing Group |
Description
LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function. |