HA-15
- N ° de catalogue:A950425
- N ° CAS. : 1609402-14-3
- Formule moléculaire:C23H22N4O3S2
- Masse moléculaire: 466.58
Remarque*
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Enquête en vrac
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
détails du produit
Numero CAS | 1609402-14-3 | Apparence | Off-white powder |
Numéro de catalogue | A950425 | Numéro MDL | MFCD30377202 |
Formule moléculaire | C23H22N4O3S2 | Masse moléculaire | 466.58 |
Point d'ébullition | Point de fusion | ||
Point de rupture | Densité | ||
Synonymes | N-(4-(3-((5-(Dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide | ||
Condition de stockage | Store in a tightly closed container,in a cool and dry place |
sécurité
Pictogramme SGH | |||
Mot de signal | Warning | Numéro UN | |
Mentions de danger | H302;H315;H319;H335 | Classe | |
Conseils de prudence | P261;P305+P351+P338 | Groupe d'emballage |
La description
Entinostat, also known as MS-275 or SNDX-275, is a potent HDAC inhibitor with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. |