CBR-5884
- Catalogo NO.:A950588
- Numero CAS : 681159-27-3
- Formula molecolare:C14H12N2O4S2
- Peso molecolare: 336.39
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Dettagli del prodotto
Numero CAS | 681159-27-3 | Aspetto | |
Numero di catalogo | A950588 | Numero MDL | MFCD04451442 |
Formula molecolare | C14H12N2O4S2 | Peso molecolare | 336.39 |
Punto di ebollizione | Punto di fusione | ||
Punto d'infiammabilità | Densità | ||
Sinonimi | Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate | ||
Condizioni di conservazione | Store in a tightly closed container,in a cool and dry place |
Sicurezza
Pittogramma GHS | |||
AVVERTENZA | Warning | Numero ONU | |
Dichiarazioni di pericolo | H302;H315;H319;H335 | Classe | |
Consigli di prudenza | P261;P305+P351+P338 | Gruppo di imballaggio |
Descrizione
Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. DM1 can also be linked to an antibody using the SMCC (4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid) linker, in which case the International Nonproprietary Name of the conjugate formed contains the word emtansine. DM1 and its attachment via these linkers result from ImmunoGen Inc research. Trastuzumab emtansine (T-DM1) is an anti-HER2/neu antibody-drug conjugate. |