4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- Catalog NO.:A946975
- CAS No. : 1440520-87-5
- Molecular Formula:C10H17BN2O2
- Molecular Weight: 208.07
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 1440520-87-5 | Appearance | White powder |
Catalog Number | A946975 | MDL Number | MFCD27977041 |
Molecular Formula | C10H17BN2O2 | Molecular Weight | 208.07 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | Methyl-1H-pyrazole-3-boronic acid pinacol ester 英文名称:4-Methyl-1H-pyrazole-3-boronic acid pinacol ester | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302;H315;H319;H335 | Class | |
Precautionary Statements | P261;P305+P351+P338 | Packing Group |
Description
BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor. BMS-582949 is currently under Phase II clinical trials for the treatment of inflammatory diseases. One clinical study showed that, in stable atherosclerosis, 12 weeks of treatment with BMS-582949 did not reduce arterial inflammation or hs-CRP compared to placebo, whereas intensification of statin therapy significantly decreased arterial inflammation. p38α MAP kinase plays a crucial role in regulating the biosynthesis of many inflammatory cytokines including TNFα and IL-1β. |