Gepotidacin hydrochloride,1075235-46-9-Amadis Chemical

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[CAS No.1075235-46-9] A1256986 Gepotidacin hydrochloride 98%

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Catalog No. A1256986

Cas No.: 1075235-46-9

Molecular Formula: C₂₄H₂₉ClN₆O₃

Molecular Weight: 484.98

MDL No:

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Quality Control of [1075235-46-9]

NMR

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LC-MS

Related Doc. of [1075235-46-9]

SDS

Specification

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Product Details [1075235-46-9]

Pubchem ID: 68596834

Storage: Store in -20°C for long term (months)

Synonyms: Gepotidacin hydrochloride; Gepotidacin HCl; GSK-2140944;(R)-2-((4-(((3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-yl)methyl)amino)piperidin-1-yl)methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione hydrochloride

Smiles: Cl.O=C1C=CC2=C3N1C[C@@H](CN4CCC(CC4)NCc5cc6CCCOc6cn5)N3C(=O)C=N2

Inchi: InChI=1S/C24H28N6O3.ClH/c31-22-4-3-20-24-29(22)15-19(30(24)23(32)13-27-20)14-28-7-5-17(6-8-28)25-11-18-10-16-2-1-9-33-21(16)12-26-18;/h3-4,10,12-13,17,19,25H,1-2,5-9,11,14-15H2;1H/t19-;/m1./s1

InchiKey: DPAHPKBTWARMFG-FSRHSHDFSA-N

Appearance:

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Safety [1075235-46-9]

Pictogram:

Signal word: Warning

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Packing Group:

Hazard statements: H302;H315;H319;H335

Precautionary statements: P261;P264;P270;P271;P280;P301+P312;P302+P352;P304+P340;P305+P351+P338;P330;P332+P313;P337+P313;P362;P403+P233;P405;P501

Literatures [1075235-46-9]

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Description [1075235-46-9]

Gepotidacin, also known as GSK-2140944, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin is a novel antibacterial drug candidate. Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively.

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