Gepotidacin mesylate dihydrate,1624306-20-2-Amadis Chemical

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[CAS No.1624306-20-2] A1256987 Gepotidacin mesylate dihydrate 98%

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Quality Control of [1624306-20-2]

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Product Details [1624306-20-2]

CAS Number: 1624306-20-2

MDL No.:

Catalog Number: A1256987

EINECS:

Molecular Formula: C₂₅H₃₆N₆O₈S

Molecular Weight: 580.65

Boiling point:

Melting point:

Flash point:

Density:

Appearance:

Storage: Store in -20°C for long term (months)

Chiral Purity:

Optical Rotation:

Refractivity:

Pubchem ID: 91668189

Synonyms: Gepotidacin methanesulfonate dihydrate;(R)-2-((4-(((3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-yl)methyl)amino)piperidin-1-yl)methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione methanesulfonate dihydrate

Smiles: O.O.CS(=O)(=O)O.O=C1C=CC2=C3N1C[C@@H](CN4CCC(CC4)NCc5cc6CCCOc6cn5)N3C(=O)C=N2

InchiKey: MTLHHQWYERWLIX-RGFWRHHQSA-N

Inchi: InChI=1S/C24H28N6O3.CH4O3S.2H2O/c31-22-4-3-20-24-29(22)15-19(30(24)23(32)13-27-20)14-28-7-5-17(6-8-28)25-11-18-10-16-2-1-9-33-21(16)12-26-18;1-5(2,3)4;;/h3-4,10,12-13,17,19,25H,1-2,5-9,11,14-15H2;1H3,(H,2,3,4);2*1H2/t19-;;;/m1.../s1

Safety [1624306-20-2]

GHS Pictogram:

Signal Word: Warning

Class:

Precautionary Statements: P261;P305+P351+P338

UN No.:

Hazard Statements: H302;H315;H319;H335

Packing Group:

Literatures [1624306-20-2]

Sorry, the literature is not available.

Similar of [1624306-20-2]

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Reason:Inhibitors/Agonists

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Reason:Inhibitors/Agonists

Description [1624306-20-2]

Gepotidacin, also known as GSK-2140944, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin is a novel antibacterial drug candidate. Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively.

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