Boc-L-glutamic acid 5-methyl ester

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For R&D use only.

Catalog NO.：A847899
CAS No. : 45214-91-3
Molecular Formula：C₁₁H₁₉NO₆
Molecular Weight： 261.27

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Product Details

CAS Number	45214-91-3	Appearance
Catalog Number	A847899	MDL Number	MFCD00190794
Molecular Formula	C₁₁H₁₉NO₆	Molecular Weight	261.27
Boiling Point	428.4°C at 760 mmHg	Melting Point	77-82°C
Flash Point		Density
Synonyms	Boc-Glu(Ome)-OH
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number	Not hazmat
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Talazoparib, also known as BMN-673 and MDV-3800, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity (PARP1 IC50 = 0.57 nmol/L). Talazoparib acts as an inhibitor of poly ADP ribose polymerase(PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage. Talazoparib is theorized to have a higher potency than olaparib due to the additional mechanism of action called PARP trapping. PARP trapping is the mechanism of action where the PARP molecule is trapped on the DNA, which interferes with the cells ability to replicate. Talazoparib is found to be ~100 fold more efficient in PARP trapping than olaparib.

1373431-65-2 (tosylate)

1207456-01-6 (free base)

1207454-56-5 (racemic)

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My Tracks: Boc-L-glutamic acid 5-methyl ester

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