3-Chloro-1,1-diethoxypropane

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For R&D use only.

Catalog NO.：A822877
CAS No. : 35573-93-4
Molecular Formula：C₇H₁₅ClO₂
Molecular Weight： 166.65

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	35573-93-4	Appearance	Colorless liquid
Catalog Number	A822877	MDL Number
Molecular Formula	C₇H₁₅ClO₂	Molecular Weight	166.65
Boiling Point	84 °C25 mm Hg(lit.)	Melting Point
Flash Point	98 °F	Density	0.995
Synonyms	3-Chloro-1,1-diethoxypropane
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	1993
Hazard Statements	H226	Class	3
Precautionary Statements	P210;P233;P240;P241;P242;P243;P280;P303+P361+P353;P370+P378;P403+P235;P501	Packing Group	III

Description

Talazoparib, also known as BMN-673 and MDV-3800, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity (PARP1 IC50 = 0.57 nmol/L). Talazoparib acts as an inhibitor of poly ADP ribose polymerase(PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage. Talazoparib is theorized to have a higher potency than olaparib due to the additional mechanism of action called PARP trapping. PARP trapping is the mechanism of action where the PARP molecule is trapped on the DNA, which interferes with the cells ability to replicate. Talazoparib is found to be ~100 fold more efficient in PARP trapping than olaparib.

1373431-65-2 (tosylate)

1207456-01-6 (free base)

1207454-56-5 (racemic)

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My Tracks: 3-Chloro-1,1-diethoxypropane

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H200	Explosives (Unstable Explosive)
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