Liquiritigenin

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For R&D use only.

Catalog NO.：A869565
CAS No. : 578-86-9
Molecular Formula：C₁₅H₁₂O₄
Molecular Weight： 256.25

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	578-86-9	Appearance	Off-white powder
Catalog Number	A869565	MDL Number	MFCD00287289
Molecular Formula	C₁₅H₁₂O₄	Molecular Weight	256.25
Boiling Point	529.5°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	(S)-7-Hydroxy-2-(4-hydroxyphenyl)chroman-4-one
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Talazoparib, also known as BMN-673 and MDV-3800, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity (PARP1 IC50 = 0.57 nmol/L). Talazoparib acts as an inhibitor of poly ADP ribose polymerase(PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage. Talazoparib is theorized to have a higher potency than olaparib due to the additional mechanism of action called PARP trapping. PARP trapping is the mechanism of action where the PARP molecule is trapped on the DNA, which interferes with the cells ability to replicate. Talazoparib is found to be ~100 fold more efficient in PARP trapping than olaparib.

1373431-65-2 (tosylate)

1207456-01-6 (free base)

1207454-56-5 (racemic)

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
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