CHIR99021
- Catalog NO.:A25048
- CAS No. : 252917-06-9
- Molecular Formula:C22H18Cl2N8
- Molecular Weight: 465.34
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 252917-06-9 | Appearance | Off-white or light yellow powder |
Catalog Number | A25048 | MDL Number | MFCD11846251 |
Molecular Formula | C22H18Cl2N8 | Molecular Weight | 465.34 |
Boiling Point | 784.1±70.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | CT99021;6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile;CHIR-99021 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
CHIR-99021, also known as CT99021, is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM. |