BMS-345541 hydrochloride

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For R&D use only.

Catalog NO.：A904000
CAS No. : 547757-23-3
Molecular Formula：C₁₄H₁₈ClN₅
Molecular Weight： 291.78

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Product Details

CAS Number	547757-23-3	Appearance
Catalog Number	A904000	MDL Number	MFCD07784499
Molecular Formula	C₁₄H₁₈ClN₅	Molecular Weight	291.78
Boiling Point	449.5°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine hydrochloride
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

BMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). It attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. BMS 345541 also suppresses joint destruction in a mouse model of arthritis.

445430-58-0 (free base)

547757-23-3 (HCl)

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