4-(4-Bromo-3-formyl-phenoxy)-benzonitrile

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For R&D use only.

Catalog NO.：A857713
CAS No. : 906673-54-9
Molecular Formula：C₁₄H₈BrNO₂
Molecular Weight： 302.12

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Product Details

CAS Number	906673-54-9	Appearance
Catalog Number	A857713	MDL Number	MFCD23131224
Molecular Formula	C₁₄H₈BrNO₂	Molecular Weight	302.12
Boiling Point	441.9±35.0°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	4-(4-Bromo-3-formyl-phenoxy)-benzonitrile;4-(4-Bromo-3-formylphenoxy)benzonitrile
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302	Class
Precautionary Statements	P280-P305+P351+P338	Packing Group

Description

Birabresib, also known as OTX015 and MK-8628, a potent BET bromodomian inhibitor, which targets the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4). BRDs 2, 3, and 4 are considered potential cancer targets because of their pivotal role in regulating the transcription of growth-promoting genes and cell cycle regulators. OTX015 is the first BRD2/3/4 inhibitor to enter clinical trials. OTX015 showed antiproliferative activity in a large panel of cell lines derived from mature B-cell lymphoid tumors with median IC50 of 240 nmol/L, without significant differences among the different histotypes.

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P501	Dispose of contents/container to..…
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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
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H300	Acute toxicity,oral (Category 1, 2)
H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
H303	Acute toxicity,oral (Category 5)
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H314	Skin corrosion/irritation (Category 1A, B, C)
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H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
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H371	Specific target organ toxicity, single exposure (Category 2)
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H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
H402	Hazardous to the aquatic environment, acute hazard (Category 3)
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