For R&D use only.


  • Catalog NO.:A2179
  • CAS No. : 110351-94-5
  • Molecular Formula:C13H13NO5
  • Molecular Weight: 263.25
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Product Details

CAS Number 110351-94-5 Appearance White powder
Catalog Number A2179 MDL Number MFCD17011873
Molecular Formula C13H13NO5 Molecular Weight 263.25
Boiling Point 666.6°C at 760 mmHg Melting Point 183-185℃ (decomposition)
Flash Point Density
Synonyms (S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
Storage Condition Store in a tightly closed container,in a cool and dry place


GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H302-H315-H319-H335 Class
Precautionary Statements P261-P305+P351+P338 Packing Group


Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.

1231929-97-7 (free base)

1231930-82-7 (mesylate)

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